INHIBITION OF SPHINGOSINE 1-PHOSPHATE RECEPTOR 3 AMELIORATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS BY SUPPRESSING MACROPHAGE M2 POLARIZATION

Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization

Pulmonary fibrosis is a devastating lung disease without effective treatment options.Sphingosine-1-phosphate receptor 3 (S1pr3), a receptor for the lipid signaling molecule sphingosine-1-phosphate, has been shown to mediate the development of pulmonary fibrosis, although the underlying mechanism is not fully understood.Here, we found increased expr

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Intracellular Spread of Rabies Virus Is Reduced in the Paralytic Form of Canine Rabies Compared to the Furious Form.

Studies of the furious and paralytic forms of canine rabies at the early stage of disease have shown a more rapid viral colonization of the cerebral hemispheres in the furious form, as measured by viral antigen within neuronal cell bodies and viral RNA levels.Measurement of cellular processes separate from neuronal cell body provides a visual recor

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Criminal Liability of the Legal Entity

Economic and financial crimes committed by individuals through training day horse supplement legal persons grew every year in Romania after the communist era while court decisions have varied in their final sentences.The lack of jurisprudence in this field has led to a slow development of legislation covering all areas that individuals and legal pe

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Non-stationary response of complex ecosystem service networks to urbanization: Evidence from a typical eco-fragile area in China

Understanding the complex interactions between urbanization and ecosystem services (ESs) is crucial for optimizing planning policies and achieving sustainable urban management.While previous research has largely focused on highly urbanized areas, little attention has been given to the phased effect of progressive urbanization on ES networks.This st

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